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Characterization by Nano-Infrared Spectroscopy of Individual Aggregated Species of Amyloid Proteins


Characterization by Nano-Infrared Spectroscopy of Individual Aggregated Species of Amyloid Proteins

J. Waeyten, A. Deniset-Besseau, A. Dazzi et leurs collaborateurs ont publié récemment un article dans Molecules :
"Characterization by Nano-Infrared Spectroscopy of Individual Aggregated Species of Amyloid Proteins"

Amyloid fibrils are composed of aggregated peptides or proteins in a fibrillar structure with a higher b-sheet content than in their native structure. With the AFM-IR, we show that we can detect different individual aggregated species like oligomers, fibrils or amorphous aggregates and study their morphologies by AFM and secondary structures based on their IR spectra. We demonstrate the advantages of AFM-IR, a high spatial resolution (≤ 10 nm) allowing spectrum recording on individual aggregated supramolecular entities selected thank to the AFM images or on thin layer of proteins.

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